England suffered a historic first defeat to Italy with a 23-18 collapse at the Stadio Olimpico raising the grim prospect of falling to their worst Six Nations finish.
An 18-10 lead built through tries from Tommy Freeman and Tom Roebuck and the boot of Fin Smith crumbled in the third quarter when Paolo Garbisi turned the tide by landing two penalties.
Italy then took advantage of Sam Underhill and Maro Itoje being sent to the sin-bin to strike the decisive blow when Leonardo Marin finished a thrilling try down the left touchline.
Jamie George, Alex Coles, Guy Pepper, Ben Spencer, Fin Smith, Cadan Murley, Seb Atkinson, Tom Roebuck and Elliot Daly will all start, while Marcus Smith is named on the bench.
The entire backline has been changed from the one that lost to Ireland with Spencer and Fin Smith starting at half-back, replacing the injured Alex Mitchell and George Ford, who has been dropped from the matchday squad.
