Italy make six changes following the heavy defeat by France in round three.
London-born winger Matt Gallagher, who qualifies through his mother, makes his Six Nations debut in place of Simone Gesi.
Monty Ioane returns after missing out against Les Bleus because of injury, meaning Ange Capuozzo moves to full-back and Tommasso Allan drops to the bench.
Stephen Varney is preferred at scrum-half to Martin Page-Relo, while there are three further changes in the pack with Giacomo Nicotera, Marco Riccioni and Ross Vintcent all coming in.
Italy: 15-Capuozzo, 14-Ioane, 13-Brex, 12-Menoncello, 11-Gallagher, 10-P Garbisi, 9-Varney; 1-Fischetti, 2-Nicotera, 3-Riccioni, 4-N Cannone, 5-Ruzza, 6-Negri, 7-Lamaro (capt) 8-Vintcent
Replacements: 16-Lucchesi, 17-Spagnolo, 18-Ferrari, 19-Favretto, 20-Zuliani, 21-L Cannone, 22-Page-Relo, 23-Allan
