Italy make seven changes following the round four defeat by England.
Captain Michele Lamaro drops to the bench for the first time in a Six Nations game – all his previous 24 caps in this tournament had been starts – and is replaced at flanker by Manuel Zuliani.
Tommaso Allan returns at full-back, with Ange Capuozzo switching to the right wing, Monty Ione to the left wing and Matt Gallagher missing out.
Martin Page-Relo replaces Stephen Varney at scrum-half, while there are a further four changes in the pack – Gianmarco Lucchesi, Simone Ferrari, Dino Lamb, and Lorenzo Cannone all come in.
Italy: 15-Allan, 14-Capuozzo, 13-Brex (capt), 12-Menoncello, 11-Ioane, 10-P Garbisi, 9-Page-Relo; 1-Fischetti, 2-Lucchesi, 3-Ferrari, 4-Lamb, 5-Ruzza, 6-Negri, 7-Zuliani, 8-L Cannone
Replacements: 16-Nicotera, 17-Spagnolo, 18-Zilocchi, 19-N Cannone, 20-Lamaro, 21-Vintcent, 22-Varney, 23-Marin
