Head coach Townsend makes three changes from the side that defeated Italy, with Tom Jordan making his first Six Nations start at inside centre, Rory Sutherland coming in at loose-head prop and Jack Dempsey at number eight.
Matt Fagerson switches to blindside flanker to accommodate Dempsey’s return, while Pierre Schoeman, Jamie Ritchie and Stafford McDowell drop to the bench.
Lock Sam Skinner and scrum-half Jamie Dobie are included among the replacements, with George Horne and Kyle Rowe missing out.
Scotland: 15-Kinghorn, 14-Graham, 13-Jones, 12-Jordan, 11-Van der Merwe; 10-Russell (co-capt), 9-White; 1-Sutherland, 2-Cherry, 3-Z. Fagerson, 4-J. Gray, 5-Gilchrist, 6-M Fagerson, 7-R Darge (co-capt), 8-Dempsey.
Replacements: 16-Ashman, 17-Schoeman, 18-Hurd, 19-Skinner, 20-Brown, 21-Ritchie, 22-Dobie, 23-McDowall.