Wainwright, 27, will pack down in the back row alongside Taulupe Faletau and captain Jac Morgan with the trio reunited from the start of a game for the first time since Wales defeated Australia 40-6 in Lyon at the 2023 World Cup.
Wainwright makes his second start of the campaign after starting at number eight in the opening 43-0 defeat by France in Paris. He only lasted a few minutes before being forced off with a facial injury.
The Dragons back-rower came off the replacements bench in the next three games with Taulupe Faletau returning to the number eight role and flankers James Botham and Tommy Reffell selected alongside captain Jac Morgan.
Sherratt decided to employ two openside flankers in Reffell and Morgan in his first two games in charge for the defeats against Ireland and Scotland.
Wainwright returns to fill the number six shirt in which he started his international career.
“Aaron has been a bit unlucky not to be selected in the last couple of games,” said Sherratt.
“It was probably just freshening up in that area, with Tommy going to the bench.”
