Ospreys flanker Jac Morgan, who has also not played for Wales in more a year, is struggling to shake off a minor injury.
Leicester open-side Tommy Reffell is in line to continue in the number seven shirt with Morgan potentially named as a replacement on a bench that could include six forwards.
Bath tight-head prop Archie Griffin has recovered from a minor temporary heart condition and could retain the number three jersey he wore against Australia, while locks Adam Beard and Will Rowlands are set to return after missing the summer programme.
Wales have lost their last nine internationals in a losing Test record that stretches back 13 months.
Another defeat will equal Wales’ record of 10 successive international losses which stretches back to Steve Hansen’s side of 2002 and 2003.
Wales open their autumn campaign against Fiji before facing Australia seven days later and finish with the visit of South Africa on 23 November.
