OTAs for the NFL began this week, but the injury bug has already hit the 49ers’ locker room.
When coach Kyle Shanahan met with the media Thursday, he informed reporters that running back Isaac Guerendo tore a pectoral muscle while lifting weights about a month ago.
Coach Kyle Shanahan said Thursday he doesn’t expect running back Isaac Guerendo to return until near the end of training camp. AP Photo/Jeff Chiu
Shanahan added that Guerendo’s injury isn’t season-ending and expects him to be back near the end of training camp.
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Guerendo was selected in the fourth round of the 2024 NFL Draft after starring at Louisville.
In his rookie season, he played in 16 games for the 49ers, who were without reigning Offensive Player of the Year Christian McCaffrey — who was sidelined for the season due to a torn Achilles.
The running back room was a revolving door in San Francisco as injuries wiped them out all season.
The 49ers had five different players lining up behind Brock Purdy at running back that year. Jordan Mason was the team’s leading rusher, and Guerendo backed him up.
Guerendo carried the ball 84 times for 420 yards and scored four touchdowns.
49ers running back Isaac Guerendo rushed for 420 yards on 84 carries in 2024, but he played only on special teams last season. Diamond Images/Getty Images
But even with the quality production, Guerendo dealt with nagging injuries all season, sometimes not finishing games and dealing with a bad hamstring, groin, ankle and shoulder.
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In 2025, Guerendo did not get a carry and spent his season playing on special teams.
Now dealing with another injury, Guerendo is looking more like a question mark to make the 49ers’ roster. He is battling Kaelon Black for the third running back spot on the depth chart.
